An Essay on the Influence of Tobacco upon Life and Health
* * * * *
From the foregoing, and from additional experiments, which it is not necessary to give in detail, it appeared, that when applied to a wound made in the most sensitive parts of the integuments, the oil of tobacco, though it caused a good deal of pain, had a far less general effect than when applied to the tongue. Rats were less affected than cats. Two and sometimes three drops rubbed upon the tongue of a rat, did not kill in half an hour.
Three large drops rubbed upon the tongue of a full-sized cat, usually caused death in from three to ten minutes, and in one instance, already stated, in two minutes and forty-five seconds. One drop passed into the jugular vein of a large dog, occasioned an immediate cry, followed in a few moments by staggering, convulsive twitchings of the voluntary muscles, and vomiting.
In those cases in which full vomiting occurred, evident relief fo